Towards Aptamer-Targeted Drug Delivery to Brain Tumors: The Synthesis of Ramified Conjugates of an EGFR-Specific Aptamer with MMAE on a Cathepsin B-Cleavable Linker

• Egile Nagusiak: Vladimir A. Brylev (Egilea), Ekaterina V. Ryabukhina (Egilea), Ekaterina V. Nazarova (Egilea), Nadezhda S. Samoylenkova (Egilea), Evgeny L. Gulyak (Egilea), Ksenia A. Sapozhnikova (Egilea), Fatima M. Dzarieva (Egilea), Alexey V. Ustinov (Egilea), Igor N. Pronin (Egilea), Dmitry Y. Usachev (Egilea), Alexey M. Kopylov (Egilea), Andrey V. Golovin (Egilea), Galina V. Pavlova (Egilea), Dmitry Yu. Ryazantsev (Egilea), Vladimir A. Korshun (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2024-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

<b>Background/Objectives:</b> Targeted delivery of chemotherapeutic agents is a well-established approach to cancer therapy. Antibody-drug conjugates (ADCs) typically carry toxic payloads attached to a tumor-associated antigen-targeting IgG antibody via an enzyme-cleavable linker that re...