The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice

• Main Authors: Adriana M. C. Canavaci (Author), Carlos A. Sorgi (Author), Vicente P. Martins (Author), Fabiana R. Morais (Author), Érika V. G. de Sousa (Author), Bruno C. Trindade (Author), Fernando Q. Cunha (Author), Marcos A. Rossi (Author), David M. Aronoff (Author), Lúcia H. Faccioli (Author), Auro Nomizo (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present work we examine the contribution of 5-lipoxygenase- (5-LO-) derived lipid mediators to immune responses during the acute phase of Trypanosoma cruzi infection in 5-LO gene knockout (5-LO−/−) mice and wild-type (WT) mice. Compared with WT mice, the 5-LO−/− mice developed less parasitemi...