The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice

• Автори: Adriana M. C. Canavaci (Автор), Carlos A. Sorgi (Автор), Vicente P. Martins (Автор), Fabiana R. Morais (Автор), Érika V. G. de Sousa (Автор), Bruno C. Trindade (Автор), Fernando Q. Cunha (Автор), Marcos A. Rossi (Автор), David M. Aronoff (Автор), Lúcia H. Faccioli (Автор), Auro Nomizo (Автор)
• Формат: Книга
• Опубліковано: Hindawi Limited, 2014-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

In the present work we examine the contribution of 5-lipoxygenase- (5-LO-) derived lipid mediators to immune responses during the acute phase of Trypanosoma cruzi infection in 5-LO gene knockout (5-LO−/−) mice and wild-type (WT) mice. Compared with WT mice, the 5-LO−/− mice developed less parasitemi...