Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid

• Main Authors: Aixa Aguilera-Garrido (Author), Elena Arranz (Author), María José Gálvez-Ruiz (Author), Juan Antonio Marchal (Author), Francisco Galisteo-González (Author), Linda Giblin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Maslinic acid (MA) is a plant-derived, low water-soluble compound with antitumor activity. We have formulated MA in the form of solid lipid nanoparticles (SLNs) with three different shell compositions: Poloxamer 407 (PMA), dicarboxylic acid-Poloxamer 407 (PCMA), and HA-coated PCMA (PCMA-HA). These S...