Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone

• Main Authors: Fernanda A. H. Batista (Author), Sérgio L. Ramos (Author), Giusy Tassone (Author), Andrei Leitão (Author), Carlos A. Montanari (Author), Maurizio Botta (Author), Mattia Mori (Author), Júlio C. Borges (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These are molecular chaperones involved in the folding...