Metformin-Mediated Improvement in Solubility, Stability, and Permeability of Nonsteroidal Anti-Inflammatory Drugs

• Main Authors: Qi An (Author), Cheng Xing (Author), Zhipeng Wang (Author), Shuang Li (Author), Wenwen Wang (Author), Shiying Yang (Author), Linglei Kong (Author), Dezhi Yang (Author), Li Zhang (Author), Guanhua Du (Author), Yang Lu (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are class II biopharmaceutics classification system drugs. The poor aqueous solubility of NSAIDs can lead to limited bioavailability after oral administration. Metformin (MET), a small-molecule compound, can be used in crystal engineering to modulate the...