Novel structured ADAM17 small-molecule inhibitor represses ADAM17/Notch pathway activation and the NSCLC cells' resistance to anti-tumour drugs

• Main Authors: Meng Chi (Author), Yamin Jie (Author), Ying Li (Author), Duo Wang (Author), Man Li (Author), Dan Li (Author), Mingyan E (Author), Yongwu Li (Author), Na Liu (Author), Anxin Gu (Author), Guanghua Rong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and aims: The outcomes of current treatment for non-small cell lung cancer (NSCLC) are unsatisfactory and development of new and more efficacious therapeutic strategies are required. The Notch pathway, which is necessary for cell survival to avert apoptosis, induces the resistance of canc...