Novel structured ADAM17 small-molecule inhibitor represses ADAM17/Notch pathway activation and the NSCLC cells' resistance to anti-tumour drugs

• Главные авторы: Meng Chi (Автор), Yamin Jie (Автор), Ying Li (Автор), Duo Wang (Автор), Man Li (Автор), Dan Li (Автор), Mingyan E (Автор), Yongwu Li (Автор), Na Liu (Автор), Anxin Gu (Автор), Guanghua Rong (Автор)
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• Опубликовано: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Предметы: article
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Background and aims: The outcomes of current treatment for non-small cell lung cancer (NSCLC) are unsatisfactory and development of new and more efficacious therapeutic strategies are required. The Notch pathway, which is necessary for cell survival to avert apoptosis, induces the resistance of canc...