Proinflammatory Responses of Heme in Alveolar Macrophages: Repercussion in Lung Hemorrhagic Episodes

• Main Authors: Rafael L. Simões (Author), Maria Augusta Arruda (Author), Cláudio Canetti (Author), Carlos H. Serezani (Author), Iolanda M. Fierro (Author), Christina Barja-Fidalgo (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinical and experimental observations have supported the notion that free heme released during hemorrhagic and hemolytic episodes may have a major role in lung inflammation. With alveolar macrophages (AM) being the main line of defense in lung environments, the influence of free heme on AM activity...