Crushed Tablets: Does the Administration of Food Vehicles and Thickened Fluids to Aid Medication Swallowing Alter Drug Release?

• Main Authors: Yady Juliana Manrique-Torres (Author), Danielle J Lee (Author), Faiza Islam (Author), Lisa M Nissen (Author), Julie A.Y. Cichero (Author), Jason R Stokes (Author), Kathryn J Steadman (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. To evaluate the influence of co-administered vehicles on in vitro dissolution in simulated gastric fluid of crushed immediate release tablets as an indicator for potential drug bioavailability compromise. Methods. Release and dissolution of crushed amlodipine, atenolol, carbamazepine and wa...