Development of metformin HCl granules using brown flaxseed mucilage as a retardant polymer: effects of polymer and drug ratio

• Main Authors: Lucas Oliveira Rodrigues (Author), Deborah Quintanilha Falcão (Author), Samanta Cardozo Mourão (Author)
• Format: Knjiga
• Izdano: Universidade de São Paulo, 2023-05-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Flaxseed (Linum usitatissimum L.) is the seed of a multipurpose plant of pharmaceutical interest, as its mucilage can be used as a natural matrix to develop extended-release dosage forms and potentially replace synthetic polymers. In this study, a 3² factorial design with two replicates of...