Opioid receptor desensitization: mechanisms and its link to tolerance

• Những tác giả chính: Stéphane eAllouche (Tác giả), Florence eNoble (Tác giả), Nicolas eMarie (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2014-12-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Opioid receptors are part of the class A of G-protein coupled receptors and the target of the opiates, the most powerful analgesic molecules used in clinic. During a protracted use, a tolerance to analgesic effect develops resulting in a reduction of the effectiveness. So understanding mechanisms of...