Opioid receptor desensitization: mechanisms and its link to tolerance
Opioid receptors are part of the class A of G-protein coupled receptors and the target of the opiates, the most powerful analgesic molecules used in clinic. During a protracted use, a tolerance to analgesic effect develops resulting in a reduction of the effectiveness. So understanding mechanisms of...
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Format: | Book |
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Frontiers Media S.A.,
2014-12-01T00:00:00Z.
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A1234.567 |
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