Ataxin-10 Inhibits TNF-α-Induced Endothelial Inflammation via Suppressing Interferon Regulatory Factor-1

• Prif Awduron: Yong Li (Awdur), Qi Zhang (Awdur), Na Li (Awdur), Liting Ding (Awdur), Jinping Yi (Awdur), Yue Xiao (Awdur), Shibiao Chen (Awdur), Xuan Huang (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Hindawi Limited, 2021-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Endothelial inflammation is a crucial event in the initiation of atherosclerosis. Here, we identify Ataxin-10 protein as a novel negative modulator of endothelial activation by suppressing IRF-1 transcription activity. The protein level of Ataxin-10 is relatively higher in human vascular endothelial...