An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

• Main Authors: Alexander Vugler (Author), James O'Connell (Author), Mai Anh Nguyen (Author), Dietmar Weitz (Author), Thomas Leeuw (Author), Elizabeth Hickford (Author), Alexander Verbitsky (Author), Xiaoyou Ying (Author), Markus Rehberg (Author), Bruce Carrington (Author), Mark Merriman (Author), Andrew Moss (Author), Jean-Marie Nicholas (Author), Phil Stanley (Author), Sara Wright (Author), Tim Bourne (Author), Yann Foricher (Author), Zhaoning Zhu (Author), Daniel Brookings (Author), Helen Horsley (Author), Jag Heer (Author), Laurent Schio (Author), Matthias Herrmann (Author), Srinivas Rao (Author), Markus Kohlmann (Author), Peter Florian (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins with both proinflammatory and immunoregulatory functions. TNF is a key mediator in autoimmune diseases and during the last couple of decades several biologic drugs have delivered new therapeutic options...