Sex-related differences in the efficacy of Baclofen enantiomers on self-administered alcohol in a binge drinking pattern and dopamine release in the core of the nucleus accumbens

• Main Authors: Jérôme Jeanblanc (Author), Pierre Sauton (Author), Charles Houdant (Author), Sandra Fernandez Rodriguez (Author), Sofia Vilelas de Sousa (Author), Virginie Jeanblanc (Author), Sandra Bodeau (Author), Laurence Labat (Author), Marion Soichot (Author), Florence Vorspan (Author), Mickael Naassila (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Clinical studies on the effectiveness of Baclofen in alcohol use disorder (AUD) yielded mixed results possibly because of differential effects of the enantiomers and sex-related differences. Here we examined the effect of the different Baclofen enantiomers on alcohol intake and on evok...