Scutellarin Ameliorates Renal Injury via Increasing CCN1 Expression and Suppressing NLRP3 Inflammasome Activation in Hyperuricemic Mice

• Main Authors: Guozheng Li (Author), Chen Guan (Author), Lingyu Xu (Author), Lin Wang (Author), Chengyu Yang (Author), Long Zhao (Author), Bin Zhou (Author), Congjuan Luo (Author), Hong Luan (Author), Wei Jiang (Author), Chenyu Li (Author), Yan Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Considerable evidences have indicated that elevated uric acid (UA) was involved in renal tubular injury leading to hyperuricemic nephropathy (HN). Scutellarin is a biologically active flavonoid derived from the Chinese traditional herb Erigeron breviscapus Hand-Mazz, which has been widely used in th...