Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model

• Auteurs principaux: Susanne Jacobsson (Auteur), Daniel Golparian (Auteur), Joakim Oxelbark (Auteur), Francois Franceschi (Auteur), David Brown (Auteur), Arnold Louie (Auteur), George Drusano (Auteur), Magnus Unemo (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Novel antimicrobials for effective treatment of uncomplicated gonorrhea are essential, and the first-in-class, oral spiropyrimidinetrione DNA gyrase B inhibitor zoliflodacin appears promising. Using our newly developed Hollow Fiber Infection Model (HFIM), the pharmacodynamics of zoliflodacin was exa...