Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model

• 主要な著者: Susanne Jacobsson (著者), Daniel Golparian (著者), Joakim Oxelbark (著者), Francois Franceschi (著者), David Brown (著者), Arnold Louie (著者), George Drusano (著者), Magnus Unemo (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Novel antimicrobials for effective treatment of uncomplicated gonorrhea are essential, and the first-in-class, oral spiropyrimidinetrione DNA gyrase B inhibitor zoliflodacin appears promising. Using our newly developed Hollow Fiber Infection Model (HFIM), the pharmacodynamics of zoliflodacin was exa...