Effect of gastric acid‐reducing agents on the pharmacokinetics and efficacy of lemborexant
Abstract Lemborexant is a dual orexin receptor antagonist approved for treating insomnia. As the solubility of lemborexant is pH‐sensitive, the impact of the gastric acid‐reducing agent (ARA), famotidine, on lemborexant pharmacokinetics was evaluated in a Phase 1 study. Additionally, post hoc analys...
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Wiley,
2020-12-01T00:00:00Z.
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