Effect of gastric acid‐reducing agents on the pharmacokinetics and efficacy of lemborexant

• Main Authors: Ishani Landry (Author), Jagadeesh Aluri (Author), Nancy Hall (Author), Dinesh Kumar (Author), Satish Dayal (Author), Margaret Moline (Author), Larisa Reyderman (Author)
• Format: Book
• Published: Wiley, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Lemborexant is a dual orexin receptor antagonist approved for treating insomnia. As the solubility of lemborexant is pH‐sensitive, the impact of the gastric acid‐reducing agent (ARA), famotidine, on lemborexant pharmacokinetics was evaluated in a Phase 1 study. Additionally, post hoc analys...