Effect of gastric acid‐reducing agents on the pharmacokinetics and efficacy of lemborexant

• প্রধান লেখক: Ishani Landry (লেখক), Jagadeesh Aluri (লেখক), Nancy Hall (লেখক), Dinesh Kumar (লেখক), Satish Dayal (লেখক), Margaret Moline (লেখক), Larisa Reyderman (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2020-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Lemborexant is a dual orexin receptor antagonist approved for treating insomnia. As the solubility of lemborexant is pH‐sensitive, the impact of the gastric acid‐reducing agent (ARA), famotidine, on lemborexant pharmacokinetics was evaluated in a Phase 1 study. Additionally, post hoc analys...