Effect of gastric acid‐reducing agents on the pharmacokinetics and efficacy of lemborexant

• Asıl Yazarlar: Ishani Landry (Yazar), Jagadeesh Aluri (Yazar), Nancy Hall (Yazar), Dinesh Kumar (Yazar), Satish Dayal (Yazar), Margaret Moline (Yazar), Larisa Reyderman (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2020-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Lemborexant is a dual orexin receptor antagonist approved for treating insomnia. As the solubility of lemborexant is pH‐sensitive, the impact of the gastric acid‐reducing agent (ARA), famotidine, on lemborexant pharmacokinetics was evaluated in a Phase 1 study. Additionally, post hoc analys...