Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

• Egile Nagusiak: Myat Nyan (Egilea), Daisuke Sato (Egilea), Mitsumasa Oda (Egilea), Tetsu Machida (Egilea), Hiroshi Kobayashi (Egilea), Takahiro Nakamura (Egilea), Shohei Kasugai (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2007-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with cal...