Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

• Main Authors: Myat Nyan (Author), Daisuke Sato (Author), Mitsumasa Oda (Author), Tetsu Machida (Author), Hiroshi Kobayashi (Author), Takahiro Nakamura (Author), Shohei Kasugai (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with cal...