A high-content small molecule screen identifies novel inducers of definitive endoderm

• Autori principali: Alexander Korostylev (Autore), Pallavi U. Mahaddalkar (Autore), Oliver Keminer (Autore), Kamyar Hadian (Autore), Kenji Schorpp (Autore), Philip Gribbon (Autore), Heiko Lickert (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2017-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objectives: Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can generate any given cell type in the human body. One challenge for cell-replacement therapy is the efficient differentiation and expansion of large quantities of progenitor cells from pluripotent stem...