A high-content small molecule screen identifies novel inducers of definitive endoderm

• Main Authors: Alexander Korostylev (Author), Pallavi U. Mahaddalkar (Author), Oliver Keminer (Author), Kamyar Hadian (Author), Kenji Schorpp (Author), Philip Gribbon (Author), Heiko Lickert (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can generate any given cell type in the human body. One challenge for cell-replacement therapy is the efficient differentiation and expansion of large quantities of progenitor cells from pluripotent stem...