COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study

• Main Authors: Kati H. Huuskonen (Author), Tarja A. Kunnas (Author), Minna M. Tanner (Author), Jussi Mikkelsson (Author), Erkki Ilveskoski (Author), Pekka J. Karhunen (Author), Seppo T. Nikkari (Author)
• Format: Book
• Published: Hindawi Limited, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis. Our objective was to study whether the functional C variant of the −765G→C polymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the...