Myeloperoxidase Promoter Polymorphism −463G Is Associated With More Severe Clinical Expression of Cystic Fibrosis Pulmonary Disease

• Main Authors: Wanda F. Reynolds (Author), Isabelle Sermet-Gaudelus (Author), Valérie Gausson (Author), Marie-Noëlle Feuillet (Author), Jean-Paul Bonnefont (Author), Gérard Lenoir (Author), Béatrice Descamps-Latscha (Author), Véronique Witko-Sarsat (Author)
• Format: Book
• Published: Hindawi Limited, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The severity of cystic fibrosis (CF) pulmonary disease is not directly related to CFTR genotype but depends upon several parameters, including neutrophil-dominated inflammation. Identification of agents modulating inflammation constitutes a relevant goal. Myeloperoxidase (MPO) is involved in both mi...