Myeloperoxidase Promoter Polymorphism −463G Is Associated With More Severe Clinical Expression of Cystic Fibrosis Pulmonary Disease

• Hoofdauteurs: Wanda F. Reynolds (Auteur), Isabelle Sermet-Gaudelus (Auteur), Valérie Gausson (Auteur), Marie-Noëlle Feuillet (Auteur), Jean-Paul Bonnefont (Auteur), Gérard Lenoir (Auteur), Béatrice Descamps-Latscha (Auteur), Véronique Witko-Sarsat (Auteur)
• Formaat: Boek
• Gepubliceerd in: Hindawi Limited, 2006-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The severity of cystic fibrosis (CF) pulmonary disease is not directly related to CFTR genotype but depends upon several parameters, including neutrophil-dominated inflammation. Identification of agents modulating inflammation constitutes a relevant goal. Myeloperoxidase (MPO) is involved in both mi...