Dopamine and Citicoline-Co-Loaded Solid Lipid Nanoparticles as Multifunctional Nanomedicines for Parkinson's Disease Treatment by Intranasal Administration

• Main Authors: Stefano Castellani (Author), Giorgia Natalia Iaconisi (Author), Francesca Tripaldi (Author), Vito Porcelli (Author), Adriana Trapani (Author), Eugenia Messina (Author), Lorenzo Guerra (Author), Cinzia Di Franco (Author), Giuseppe Maruccio (Author), Anna Grazia Monteduro (Author), Filomena Corbo (Author), Sante Di Gioia (Author), Giuseppe Trapani (Author), Massimo Conese (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work aimed to evaluate the potential of the nanosystems constituted by dopamine (DA) and the antioxidant Citicoline (CIT) co-loaded in solid lipid nanoparticles (SLNs) for intranasal administration in the treatment of Parkinson disease (PD). Such nanosystems, denoted as DA-CIT-SLNs, were design...