Celastrol Attenuates Lipid Accumulation and Stemness of Clear Cell Renal Cell Carcinoma via CAV-1/LOX-1 Pathway

• Main Authors: Chan-Juan Zhang (Author), Neng Zhu (Author), Yu-Xiang Wang (Author), Le-Ping Liu (Author), Tan-Jun Zhao (Author), Hong-Tao Wu (Author), Duan-Fang Liao (Author), Li Qin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clear cell renal cell carcinoma (ccRCC) is characterized by abnormal lipid accumulation. Celastrol is a pentacyclic triterpene extracted from Tripterygium wilfordii Hook F with anti-cancer activity. In the present study, the anticancer effects of celastrol on ccRCC and the underlying mechanisms were...