Hepatic Organoid-Based High-Content Imaging Boosts Evaluation of Stereoisomerism-Dependent Hepatotoxicity of Stilbenes in Herbal Medicines

• Main Authors: Juan Liu (Author), Tingting Li (Author), Ruihong Li (Author), Jie Wang (Author), Pengyan Li (Author), Ming Niu (Author), Le Zhang (Author), Chunyu Li (Author), Tao Wang (Author), Xiaohe Xiao (Author), Jia-bo Wang (Author), Yunfang Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The complexity of chemical components of herbal medicines often causes great barriers to toxicity research. In our previous study, we have found the critical divergent hepatotoxic potential of a pair of stilbene isomers in a famous traditional Chinese herb, Polygonum multiflorum (Heshouwu in Chinese...