Pharmacological Modulation of Blood-Brain Barrier Permeability by Kinin Analogs in Normal and Pathologic Conditions

• Main Authors: Dina Sikpa (Author), Lisa Whittingstall (Author), Martin Savard (Author), Réjean Lebel (Author), Jérôme Côté (Author), Stephen McManus (Author), Sylvain Chemtob (Author), David Fortin (Author), Martin Lepage (Author), Fernand Gobeil (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The blood-brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous system diseases. Peptide agonist analogs of kinin B1 and B2 receptors, acting as BBB permeabilizers, have been utilized to overcome this barrier....