The NF-κB Inhibitor Curcumin Blocks Sepsis-Induced Muscle Proteolysis

• Главные авторы: Vitaliy Poylin (Автор), Moin U. Fareed (Автор), Patrick O'Neal (Автор), Nima Alamdari (Автор), Natasha Reilly (Автор), Michael Menconi (Автор), Per-Olof Hasselgren (Автор)
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• Опубликовано: Hindawi Limited, 2008-01-01T00:00:00Z.
• Предметы: article
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We tested the hypothesis that treatment of rats with curcumin prevents sepsis-induced muscle protein degradation. In addition, we determined the influence of curcumin on different proteolytic pathways that are activated in septic muscle (i.e., ubiquitin-proteasome-, calpain-, and cathepsin L-depende...