Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice

• Main Authors: Jung-Yeon Kim (Author), Jungmin Jo (Author), Kiryeong Kim (Author), Hyun-Jin An (Author), Mi-Gyeong Gwon (Author), Hyemin Gu (Author), Hyun-Ju Kim (Author), A Young Yang (Author), Sung-Woo Kim (Author), Eon Ju Jeon (Author), Jae-Hyung Park (Author), Jaechan Leem (Author), Kwan-Kyu Park (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirtuin 1 (Sirt1) is an essential modulator of cellular metabolism and has pleiotropic effects. It was recently reported that Sirt1 overexpression in kidney tubule ameliorates cisplatin-induced acute kidney injury (AKI). However, whether pharmacological activation of Sirt1 also has a beneficial effe...