Genotoxic potential of a novel PDE-4B inhibitor Apremilast by chromosomal aberration and micronucleus assay in mice

• Main Authors: Muhammad Afzal (Author), Imran Kazmi (Author), Khalid Saad Alharbi (Author), Anwarulabedin Mohsin Quazi (Author), Muhammad Shahid Nadeem (Author), Nasser Hadal Alotaibi (Author), Ameeduzzafar (Author), Nabil K. Alruwaili (Author), Firoz Anwar (Author), Sattam Khulaif Alenezi (Author), Mohammad M. Al-sanea (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Researchers have confirmed that chronic administration of drugs at high doses causes genotoxicity which serve as first step in development of cancers. Apremilast, a phosphodiesterase-4 inhibitor is Food and Drug Administration (FDA) approved drug for Psoriatic Arthritis. The present study...