Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni.

• Main Authors: Thavy Long (Author), R Jeffrey Neitz (Author), Rachel Beasley (Author), Chakrapani Kalyanaraman (Author), Brian M Suzuki (Author), Matthew P Jacobson (Author), Colette Dissous (Author), James H McKerrow (Author), David H Drewry (Author), William J Zuercher (Author), Rahul Singh (Author), Conor R Caffrey (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Schistosoma flatworm parasites cause schistosomiasis, a chronic and debilitating disease of poverty in developing countries. Praziquantel is employed for treatment and disease control. However, its efficacy spectrum is incomplete (less active or inactive against immature stages of the par...