Pharmacokinetics, pharmacodynamics and bioavailability of dexmedetomidine nasal spray in healthy Chinese adults: A phase I clinical trial

• Main Authors: Yan Li (Author), Lu Qi (Author), Zhenyu Wang (Author), Wan Wang (Author), Langxi Zhang (Author), Leting Yang (Author), Chen Liu (Author), Wenjing Zhong (Author), Xinghe Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundIntranasal administration is a convenient route for drug delivery that can be applied for procedural sedation. However, there is currently limited exploration into fixed dosing regimens. This study was to investigate the pharmacokinetics (PK), pharmacodynamics (PD), bioavailability (BA) an...