Antidiuretic Effects of a Novel Nonpeptide Vasopressin V2-Receptor Agonist, OPC-51803, Administered Orally to Dogs

• Main Authors: Shigeki Nakamura (Author), Takahiro Hirano (Author), Toshiyuki Onogawa (Author), Shuji Itoh (Author), Ayako Hashimoto (Author), Yoshitaka Yamamura (Author), Kazumi Kondo (Author), Toyoki Mori (Author), Toshimi Kambe (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We elucidated the pharmacological properties of a novel nonpeptide vasopressin V2-receptor agonist, OPC-51803 ((5R)-2-[1-(2-chloro-4-(1-pyrrolidinyl)benzoyl-2,3,4,5-tetra-hydro-1H-1-benzazepine-5-yl]-N-isopropylacetamide), via both in vitro binding experiments incorporating canine kidney and platele...