P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN)

• المؤلفون الرئيسيون: Ann E. Walts M.D (مؤلف), Juan Lechago* (مؤلف), Bing Hu (مؤلف), MaryBeth Shwayder (مؤلف), Lynn Sandweiss (مؤلف), Shikha Bose (مؤلف)
• التنسيق: كتاب
• منشور في: SAGE Publishing, 2008-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background Significant variation is reported in the diagnosis of HPV-associated AIN. We previously observed that band-like positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN. This study was undertaken...