LC-MS characterization of valsartan degradation products and comparison with LC-PDA

• Main Authors: Sumaia Araújo Pires (Author), Letícia Martins Mota (Author), Jerusa Simone Garcia (Author), Phellipe Honorio Amaral (Author), Eduardo César Meurer (Author), Marcos Nogueira Eberlin (Author), Marcello Garcia Trevisan (Author)
• Format: Book
• Published: Universidade de São Paulo, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

abstract Valsartan was submitted to forced degradation under acid hydrolysis condition as prescribed by the ICH. Degraded sample aliquots were separated via HPLC using a Hypersil ODS (C18) column (250 x 4.6 mm i.d., 5 µm). Either photodiode array (PDA) detection or mass spectrometry (MS) full scan m...