Transcriptional signatures of unfolded protein response implicate the limitation of animal models in pathophysiological studies

• Main Authors: Ze Zheng (Author), Guohui Wang (Author), Li Li (Author), Jeffery Tseng (Author), Fei Sun (Author), Xuequn Chen (Author), Lin Chang (Author), Henry Heng (Author), Kezhong Zhang (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The unfolded protein response (UPR) refers to intracellular stress signaling pathways that protect cells from the stress caused by accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER). The UPR signaling is crucially involved in the initiation and progression o...