Trifluoromethyl-substituted 3,5-bis(arylidene)-4-piperidones as potential anti-hepatoma and anti-inflammation agents by inhibiting NF-кB activation

• Main Authors: Wei Cong (Author), Yue Sun (Author), Yi-Fan Sun (Author), Wei-Bin Yan (Author), Yu-Long Zhang (Author), Zhong-Fei Gao (Author), Chun-Hua Wang (Author), Gui-Ge Hou (Author), Jia-Jing Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Some methoxy-, hydroxyl-, pyridyl-, or fluoro-substituted 3,5-bis(arylidene)-4-piperidones (BAPs) could reduce inflammation and promote hepatoma cell apoptosis by inhibiting activation of NF-κB, especially after introduction of trifluoromethyl. Herein, a series of trifluoromethyl-substituted BAPs (4...