Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain

• Glavni autori: Yang Yang (Autor), Wei Zhou (Autor), Xiuqi Xu (Autor), Xianxiu Ge (Autor), Fei Wang (Autor), Guang-Qin Zhang (Autor), Lin Miao (Autor), Xueting Deng (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Substance P contributes to the pathogenesis of pain by acting on NK-1R, specialized sensory neurons that detect noxious stimuli. Aprepitant, an antagonist of NK-1R, is widely used to treat chemotherapy-induced nausea and vomiting. In this study, we used LPS-stimulated BV-2 microglia cell line and an...