Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells

• Main Authors: Nihal AlMuraikhi (Author), Nuha Almasoud (Author), Sarah Binhamdan (Author), Ghaydaa Younis (Author), Dalia Ali (Author), Muthurangan Manikandan (Author), Radhakrishnan Vishnubalaji (Author), Muhammad Atteya (Author), Abdulaziz Siyal (Author), Musaad Alfayez (Author), Abdullah Aldahmash (Author), Moustapha Kassem (Author), Nehad M. Alajez (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Hedgehog (Hh) signaling is essential for osteoblast differentiation of mesenchymal progenitors during endochondral bone formation. However, the critical role of Hh signaling during adult bone remodeling remains to be elucidated. Methods. A Smoothened (SMO) antagonist/Hedgehog inhibitor,...