LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP

• Main Authors: Yang Tan (Author), Yan Xu (Author), Chi Cheng (Author), Cong Zheng (Author), Weiqi Zeng (Author), Ji Wang (Author), Xiaoqian Zhang (Author), Xiaoman Yang (Author), Jialing Wang (Author), Xiaomei Yang (Author), Shuke Nie (Author), Xuebing Cao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glutamate overactivity in basal ganglia critically contributes to the exacerbation of dopaminergic neuron degeneration in Parkinson's disease (PD). Activation of group II metabotropic glutamate receptors (mGlu2/3 receptors), which can decrease excitatory glutamate neurotransmission, provides an...