Ginsenoside Rg5 enhances the radiosensitivity of lung adenocarcinoma via reducing HSP90-CDC37 interaction and promoting client protein degradation

• Main Authors: Hansong Bai (Author), Jiahua Lyu (Author), Xinyu Nie (Author), Hao Kuang (Author), Long Liang (Author), Hongyuan Jia (Author), Shijie Zhou (Author), Churong Li (Author), Tao Li (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ginsenoside Rg5 is a rare ginsenoside showing promising tumor-suppressive effects. This study aimed to explore its radio-sensitizing effects and the underlying mechanisms. Human lung adenocarcinoma cell lines A549 and Calu-3 were used for in vitro and in vivo analysis. Bioinformatic molecular dockin...