Ergot Alkaloids (Re)generate New Leads as Antiparasitics.

• Main Authors: John D Chan (Author), Prince N Agbedanu (Author), Thomas Grab (Author), Mostafa Zamanian (Author), Peter I Dosa (Author), Timothy A Day (Author), Jonathan S Marchant (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Praziquantel (PZQ) is a key therapy for treatment of parasitic flatworm infections of humans and livestock, but the mechanism of action of this drug is unresolved. Resolving PZQ-engaged targets and effectors is important for identifying new druggable pathways that may yield novel antiparasitic agent...