Synthesis, characterization and in vivo evaluation of honokiol bisphosphate prodrugs protects against rats' brain ischemia-reperfusion injury

• Main Authors: Gaojie Xu (Author), Renghan Dong (Author), Jin Liu (Author), Li Zhao (Author), Yan Zeng (Author), Xiaofan Xiao (Author), Jinglin An (Author), Sheng Huang (Author), Yueling Zhong (Author), Bing Guang (Author), Tai Yang (Author)
• Format: Book
• Published: Elsevier, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Honokiol (HK) usage is greatly restricted by its poor aqueous solubility and limited oral bioavailability. We synthesized and characterized a novel phosphate prodrug of honokiol (HKP) for in vitro and in vivo use. HKP greatly enhanced the aqueous solubility of HK (127.54 ± 15.53 mg/ml) and the stabi...