Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models

• Main Authors: Laura Magri (Author), Manuela Cominelli (Author), Marco Cambiaghi (Author), Marco Cursi (Author), Letizia Leocani (Author), Fabio Minicucci (Author), Pietro Luigi Poliani (Author), Rossella Galli (Author)
• Format: Book
• Published: The Company of Biologists, 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidity, and is caused by mutations in either of two genes, TSC1 or TSC2. Most affected individuals display severe neurological manifestations - such as intractable epilepsy, mental retardation and...