Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models

• 主要な著者: Laura Magri (著者), Manuela Cominelli (著者), Marco Cambiaghi (著者), Marco Cursi (著者), Letizia Leocani (著者), Fabio Minicucci (著者), Pietro Luigi Poliani (著者), Rossella Galli (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2013-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

SUMMARY Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidity, and is caused by mutations in either of two genes, TSC1 or TSC2. Most affected individuals display severe neurological manifestations - such as intractable epilepsy, mental retardation and...