Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models

• Главные авторы: Laura Magri (Автор), Manuela Cominelli (Автор), Marco Cambiaghi (Автор), Marco Cursi (Автор), Letizia Leocani (Автор), Fabio Minicucci (Автор), Pietro Luigi Poliani (Автор), Rossella Galli (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2013-09-01T00:00:00Z.
• Предметы: article
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SUMMARY Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidity, and is caused by mutations in either of two genes, TSC1 or TSC2. Most affected individuals display severe neurological manifestations - such as intractable epilepsy, mental retardation and...