A mouse model for monitoring islet cell genesis and developing therapies for diabetes

• Main Authors: Yoshinori Shimajiri (Author), Yasuhiro Kosaka (Author), David W. Scheel (Author), Francis C. Lynn (Author), Nina Kishimoto (Author), Juehu Wang (Author), Shuhong Zhao (Author), Michael S. German (Author)
• Format: Book
• Published: The Company of Biologists, 2011-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Transient expression of the transcription factor neurogenin-3 marks progenitor cells in the pancreas as they differentiate into islet cells. We developed a transgenic mouse line in which the surrogate markers secreted alkaline phosphatase (SeAP) and enhanced green florescent protein (EGFP) c...