A mouse model for monitoring islet cell genesis and developing therapies for diabetes

• मुख्य लेखकों: Yoshinori Shimajiri (लेखक), Yasuhiro Kosaka (लेखक), David W. Scheel (लेखक), Francis C. Lynn (लेखक), Nina Kishimoto (लेखक), Juehu Wang (लेखक), Shuhong Zhao (लेखक), Michael S. German (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2011-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

SUMMARY Transient expression of the transcription factor neurogenin-3 marks progenitor cells in the pancreas as they differentiate into islet cells. We developed a transgenic mouse line in which the surrogate markers secreted alkaline phosphatase (SeAP) and enhanced green florescent protein (EGFP) c...