Identification of a novel PAK1 inhibitor to treat pancreatic cancer

• Main Authors: Jiaqi Wang (Author), Yonghua Zhu (Author), Jiao Chen (Author), Yuhan Yang (Author), Lingxia Zhu (Author), Jiayu Zhao (Author), Yang Yang (Author), Xueting Cai (Author), Chunping Hu (Author), Rafael Rosell (Author), Xiaoyan Sun (Author), Peng Cao (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic cancer is one of the most aggressive cancers with poor prognosis and a low 5-year survival rate. The family of P21-activated kinases (PAKs) appears to modulate many signaling pathways that contribute to pancreatic carcinogenesis. In this work, we demonstrated that PAK1 is a critical regul...