Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet

• Main Authors: Hiroaki Kawaguchi (Author), Noriaki Miyoshi (Author), Naoki Miura (Author), Makoto Fujiki (Author), Masahisa Horiuchi (Author), Yasukatsu Izumi (Author), Hiroaki Miyajima (Author), Ryoichi Nagata (Author), Kazuhiro Misumi (Author), Toru Takeuchi (Author), Akihide Tanimoto (Author), Hiroki Yoshida (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atherosclerotic lesions were observed in male and ovariectomized female Microminipig (MMP) fed a high fat and cholesterol diet with sodium cholate (HFCD/SC) for 3 months. HFCD/SC induced hypercholesterolemia accompanied by an increase in serum total cholesterol (T-Cho), low-density lipoprotein chole...