New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors

• Autors principals: Momen R. Fareed (Autor), Mai E. Shoman (Autor), Mohammed I. A. Hamed (Autor), Mohamed Badr (Autor), Hanin A. Bogari (Autor), Sameh S. Elhady (Autor), Tarek S. Ibrahim (Autor), Gamal El-Din A (Autor), Taha F. S. Ali (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2021-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

A series of 3-benzylideneindolin-2-one compounds was designed and synthesized based on combretastatin A-4 and compound <b>IC261</b>, a dual casein kinase (CK1)/tubulin polymerization inhibitor, taking into consideration the pharmacophore required for EGFR-tyrosine kinase inhibition. The...