New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors
A series of 3-benzylideneindolin-2-one compounds was designed and synthesized based on combretastatin A-4 and compound <b>IC261</b>, a dual casein kinase (CK1)/tubulin polymerization inhibitor, taking into consideration the pharmacophore required for EGFR-tyrosine kinase inhibition. The...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2021-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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